Two sample MR report
AKR1C3_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.2790893 | 0.1339303 | 0.0668478 |
| Weighted median | 11 | 0.0947073 | 0.0254047 | 0.0001931 |
| Inverse variance weighted | 11 | 0.0688513 | 0.0232072 | 0.0030091 |
| Simple mode | 11 | 0.1220026 | 0.0388024 | 0.0104353 |
| Weighted mode | 11 | 0.1169216 | 0.0395900 | 0.0144526 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.743545 | 9 | 0.3716429 |
| Inverse variance weighted | 17.191165 | 10 | 0.0702396 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.3882258 | 0.1480174 | 0.0276818 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001204 | 0 | TRUE | 0.3004619 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
